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Dr. S.B. Prasad

FACULTY

 

Name:  Dr. S. B. Prasad

Designation:  Professor

Specialization:  Cell and Tumour Biology

 

Contact Information:

Department of Zoology,
School of Life Sciences
North-Eastern Hill University
Shillong 793022, INDIA

Tel.: +91 364 272 2318 (work), +91 364 2550093 (home)
Fax: +91 364 2550076/2550108

E-Mail: sbprasad@nehu.ac.in ; sbpnehu@hotmail.com

 

Academic Qualifications:

Degree

Year

University

B. Sc.

1976

Banaras Hindu University , Varanasi-5

M. Sc.

1978

-do-

Ph. D.

1981

-do-

 

Fellowships/Awards/Recognitions:

National:

  • UGC National Associateship
  • BOYSCAST Fellowship
  • SERC Visiting Fellowship

 

Memberships of academic societies, etc.:

  • Member of the European Society for Comparative Endocrinology.
  • Indian Society of Cell Biology
  • Indian Science Congress Association
  • Indian Association for Cancer Research

Was selected as a member of the International Scientific Committee of I st, II nd, III rd, IV th and VII th “International Symposium on metal ions in Biology and Medicine”, held in 1990, 1992, 1994, 1996 and 2002 in France, Canada, Greece, Spain and Russia.

  • National Executive committee member of Indian Association for Cancer Research, 2009 to 2012.

 

Major areas of research interests:

  • Anticancer effect of cisplatin, cyclophosphamide and chlorambucil in murine malignant tumor.
  • Role of glutathione in the anticancer activity of cisplatin and other chemo-therapeutic agents.
  • Role of supplementary ascorbic acid in the therapeutic efficacy of cisplatin, cyclophosphamide, chlorambucil etc.
  • Efficacy of putative anticancer medicinal plants and insects in North-east region of India and establishment of their possible mode of action.

 

Achievements in Research :

The research work broadly covers following aspects of work:

  • The antitumor activity of the anticancer drug, cisplatin was shown to be related with its definite effect on the surface of tumor cells in terms of lectin binding sites, lectin agglutinability, cell surface mucopolysaccharides/sialic acid residues and membrane related enzymes. Cisplatin-mediated interaction of monocytes, lymphocytes with tumor cells and their membrane changes is also being studied.
  • It was also found that in tumor-bearing hosts about two fold higher serum LDH is present as compared to that in normal animals, and following cisplatin treatment serum LDH activity further increases. LDH isozyme patterns showed the appearance of some specific isozyme variant, named as LDH-T, in the serum of tumor-bearing hosts.
  • Combination chemotherapy of cisplatin/cyclophosphamide/chlorambucil with vitamin C against murine ascites Dalton’s lymphoma is also being studied in an attempt to decrease their toxic effects in the hosts without decreasing their therapeutic efficacy.
  • Ascorbic acid enhances cisplatin and cyclophosphamide-mediated therapeutic efficacy. Ascorbic acid-mediated decrease in the level of glutathione in tumor cells may play a significant role in the antitumor activity of cyclophosphamide. Lipid peroxidation increased in the host tissues after cyclophosphamide alone treatment while significant decrease was noted after ascorbic acid and cyclophosphamide combination treatment suggesting that cyclophosphamide treatment is associated with induction of oxidative stress that can be ameliorated supplementary ascorbic acid treatment.
  • Cisplatin treatment also showed biochemical and ultrastructural changes in the mitochondria of Dalton’s lymphoma and other host tissues. Decrease level of mitochondrial lipid peroxidation and glutathione as well as succinate dehydrogenase and malate dehydrogenase activities could be an important factor(s) in the development of toxic/cytotoxic effects in the host during cisplatin-mediated cancer chemotherapy.
  • The studies on the evaluation of some medicinal plants from north-eastern India, particulary, Meghalaya, Assam and Mizoram, to ascertain their anticancer activity has also been undertaken. Out of many plants being used, Dillenia pentagyna, Potentilla fulgens and Oroxylum indicum showed promising antitumor potential against murine tumor system. Dillenia pentagyna extract-mediated decrease level of glutathione in Dalton’s lymphoma cells may play a role in decreased antioxidant machinery, thereby leading toward tumor cell death. Dillenia pentagyna extract also showed potent antimutagenic activity against cisplatin and benzo[a]pyrene-induced mutagenicity in mice.
  • Cantharidin isolated from an insect ‘ Mylabris cichorii’ showed effective antitumor activity against murine ascites Dalton’s lymphoma. Cantharidin-induced decrease in activity of lactate dehydrogenase, malate dehydrogenase and decreased mitochondrial membrane potential may play a role in the apoptotic property of cantharidin in tumor cells.

 

Number of M. Phil. /Ph. D. produced:

Ph. D.: 8

Name

Year

Title of Thesis

Mr. J. Arjun

 

1989

 

Studies on the effect of cisplatin on lymphoid organs and dalton’s lymphoma in mice : Additive antitumour activity by cisplatin and Vitamin C.

Dr. A. Giri

 

1995

 

1995 Studies on the effect of cisplatin on malignant and normal cells : Preliminary investigations on cisplatin combination chemotherapy.

Dr. D. Khynriam

2001

Studies on the anticancer activity of cisplatin in relation to glutathione.

Dr. (Mrs.) S. Giri

 

2002

 

Studies on the genotoxic effects of some pesticides in mice and chick in vivo by multiple cytogenetic end point analysis.

Dr. (Mrs.) A. Kharbangar

2004

 

Studies on the effect of cisplatin on mitochondria In Dalton’s lymphoma-bearing mice.

Dr. Bonnie M. Nicol

2005

 

Studies on the effect of ascorbic acid with cyclophosphamide against murine ascites Dalton’s lymphoma

Dr. G. Rosangkima

2008

 

Studies on antitumor and antimutagenic potentials of some plants of Meghalaya and Mizoram

Mrs. K.R.M. Martha

2011

Studies on biochemical and structural changes in mitochondria in relation to combination treatment with dietary ascorbic acid and cisplatin in tumor-bearing mice (Submitted)

 

Number of Ph. D. students working for the degree: 6

Name

Title of Ph. D. Dissertation

Ms. Amenla

“Studies on the antitumor activity and toxicity using combination treatment of ascorbic acid and cisplatin in tumor-bearing mice”

Mr. T. Rongpi

“Studies on the antitumor potentials of some selected plants and their active principle(s) against murine ascites Dalton’s lymphoma”.

Mr. B. Brahma

“In vivo and in vitro assessment of anticancer activity of some medicinal plants and their active component(s)”.

Mr. A. K. Verma

“Studies on the antitumor efficacy and toxicity of the blister beetle, Mylabris cichorii extract in mice bearing ascites Dalton’s lymphoma”.

Ms. S. Kalita

“Studies on the modulatory effect of vitamin C on the antitumor and toxic activities of chlorambucil in tumor-bearing mice”.

Ms. Ibanrikynti Turnia

Admitted and yet to be registered

 

Major Research Projects undertaken:

  1. Title: "Studies on the cell surface of Malignant and normal cells Using cisplatin as a probe".

    Funding agency: UGC, New Delhi
    Duration: 1989 - 1992 (3 years)
    Total grant: Rs. 2.5 Lakhs
  2. Title: “Evaluation of antitumor activity and isolation of active principle(s) from some indigenous traditional medicinal plants of Northeast India”.

Funding agency:UGC, Post doctoral Research fellowship in the lab.
Duration:2009 – 2011 (2 years)
Total grant:Rs 2.76 Lakhs.

.

Publications:

National: 10
International: 32

Updated by lakmen_zoology on Sep 16, 2013 13:17:33